反应详情

To a solution of methyl 7-ethyl-3-methyl-1H-indazole-5-carboxylic acid (240 mg, 1.10 mmol) in EtOH (13 mL) was added 1 M LiOH (2.2 mL). The mixture was heated overnight at reflux and cooled to room temperature. The solvents were removed under reduced pressure and the resultant material was suspended in 1 N HCl. The solids were isolated by vacuum filtration, washed with water, dried at 45° C. under vacuum to afford the title compound (154 mg, 69%) containing ˜10% of des-methyl material.

1. temperatureThe mixture was heated overnight
2. temperatureat reflux
3. customThe solvents were removed under reduced pressure
4. customThe solids were isolated by vacuum filtration
5. washwashed with water
6. customdried at 45° C. under vacuum