Lithium Hydroxide → HCID 66920564, compound

HRID 1880415Notes

Reaction equation

HRID 1880415 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:13]([O:15]CC)=[O:14])[CH:7]=[C:8]2[C:12]=1[NH:11][N:10]=[CH:9]2)[CH3:2].[Li+].[OH-]>>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([C:13]([OH:15])=[O:14])[CH:7]=[C:8]2[C:12]=1[NH:11][N:10]=[CH:9]2)[CH3:2]

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 66920431HCID 66920431, compound

Product 1

HCID 66920564HCID 66920564, compoundYield 99.3%

Procedure

To a solution of ethyl 7-ethoxy-1H-indazole-5-carboxylate (400 mg, 1.71 mmol) was added 1 M LiOH (3.4 mL). The mixture was heated at reflux overnight. The reaction was concentrated to dryness and the solids were triturated with 1 N HCl. The solids were washed with water and air dried to afford the title compound as an off-white solid (350 mg, 99%).

Workup

  1. temperatureThe mixture was heated
  2. temperatureat reflux overnight
  3. concentrationThe reaction was concentrated to dryness
  4. customthe solids were triturated with 1 N HCl
  5. washThe solids were washed with water and air
  6. customdried

Sources & evidence

ORD record
ord-5f82da065b284ea8a5ae00e884c24ec7
Source dataset
uspto-grants-2012_11
Patent number
US08318762B2

Reaction notes

Loading…