反应详情

To a solution of 2-ethyl-6-methylaniline (2.03 g, 15 mmol) in DMF (50 mL) at 0° C. was added N-bromosuccinimide (2.66 g, 14.9 mmol). The mixture was stirred at room temperature for 10 minutes before addition to saturated aqueous NaCl. The mixture was extracted with EtOAc, the organic phase was washed with sat aqueous NaCl (2×), concentrated and the crude material was purified by Biotage chromatography (40M, 15% EtOAc/heptane) to provide 4-bromo-2-ethyl-6-methylbenzenamine as a red brown liquid (3.21 g, 100%).

1. extractionThe mixture was extracted with EtOAc
2. washthe organic phase was washed with sat aqueous NaCl (2×)
3. concentrationconcentrated
4. customthe crude material was purified by Biotage chromatography (40M, 15% EtOAc/heptane)