1,4-Dioxane → 5-Chloro-N-{2-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-2-thiophenecarboxamide

HRID 188042Notes

Reaction equation

HRID 188042 reaction equation
[CH3:21][N:22]1[CH:23]([CH2:27][CH2:28][NH2:29])[CH2:24][CH2:25][CH2:26]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[NH:9][c:10]2[cH:11][cH:12][cH:13][c:14]3[c:18]2[C:17](=[O:19])[O:16][C:15]3=[O:20])[s:6]1.[O:30]1[CH2:31][CH2:32][O:33][CH2:34][CH2:35]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[NH:9][c:10]2[cH:11][cH:12][cH:13][c:14]3[c:18]2[C:17](=[O:19])[N:29]([CH2:28][CH2:27][CH:23]2[N:22]([CH3:21])[CH2:26][CH2:25][CH2:24]2)[C:15]3=[O:20])[s:6]1

Participants

4

Reactant 3

HCID 312751,4-DioxaneHCID 983882-(2-Aminoethyl)-1-methylpyrrolidineHCID 113926535-Chloro-N-(1,3-dioxo-1,3-dihydro-2-benzofuran-4-yl)-2-thiophenecarboxamide

Product 1

HCID 120748895-Chloro-N-{2-[2-(1-methyl-2-pyrrolidinyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}-2-thiophenecarboxamide

Sources & evidence

ORD record
ord-5b247d39b3a6481ba4b85574b8291e40
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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