Hydrochloric Acid → HCID 66589488, compound

HRID 1880623Notes

Reaction equation

HRID 1880623 reaction equation
[O:1]=[C:2]1[CH:7]([N:8]2[CH2:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([CH2:17][NH:18][C:19](=[O:45])[NH:20][C:21]4[CH:22]=[CH:23][C:24]([CH3:44])=[C:25]([CH:43]=4)[O:26][C:27](=[O:42])[CH2:28][N:29]4CCN(C(OC(C)(C)C)=O)CC4)[CH:14]=3)[C:9]2=[O:46])[CH2:6][CH2:5][C:4](=[O:47])[NH:3]1.[ClH:48]>C(Cl)Cl.CCOCC>[ClH:48].[NH2:29][CH2:28][C:27]([O:26][C:25]1[CH:43]=[C:21]([NH:20][C:19]([NH:18][CH2:17][C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[C:9](=[O:46])[N:8]([CH:7]2[CH2:6][CH2:5][C:4](=[O:47])[NH:3][C:2]2=[O:1])[CH2:16]3)=[O:45])[CH:22]=[CH:23][C:24]=1[CH3:44])=[O:42]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 66589469HCID 66589469, compound

Product 1

HCID 66589488HCID 66589488, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

To a mixture of tert-butyl 4-(2-(5-(3-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)ureido)-2-methylphenoxy)-2-oxoethyl)piperazine-1-carboxylate (0.65 g, 1.0 mmol) in methylene chloride (50 mL) is added 2M HCl in ether (1 mL), and the mixture will be stirred for 24 hrs. The solid precipitate is filtered, rinsed with DCM (10 mL), and dried under vacuum to provide the product.

Workup

  1. filtrationThe solid precipitate is filtered
  2. washrinsed with DCM (10 mL)
  3. customdried under vacuum
  4. customto provide the product

Sources & evidence

ORD record
ord-b699e8d90c9e436d8074c21c93ed00c8
Source dataset
uspto-grants-2012_11
Patent number
US08318773B2

Reaction notes

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