Hydrochloric Acid → HCID 69234347, compound

HRID 1880648Notes

Reaction equation

HRID 1880648 reaction equation
C(OC([N:8]1[CH2:15][CH:14]2[CH:10]([CH2:11][N:12]([C:16]3[S:17][CH:18]=[CH:19][N:20]=3)[CH2:13]2)[CH2:9]1)=O)(C)(C)C.[ClH:21]>>[ClH:21].[S:17]1[CH:18]=[CH:19][N:20]=[C:16]1[N:12]1[CH2:11][CH:10]2[CH:14]([CH2:15][NH:8][CH2:9]2)[CH2:13]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 69235537HCID 69235537, compound

Product 1

HCID 69234347HCID 69234347, compoundYield 41%

Procedure

400 mg (1.36 mmol) 5-thiazol-2-yl-hexahydro-pyrrolo[3,4-c]pyrrole-2-carboxylic acid tert-butyl-ester was dissolved in an ethereal HCl soln. After stirring for 1 h at RT, the resulting precipitate was filtered off and subsequently washed with ether. 130 mg (0.56 mmol, 41%) 2-thiazol-2-yl-octahydro-pyrrolo[3,4-c]pyrrole hydrochloride was thus obtained.

Workup

  1. filtrationthe resulting precipitate was filtered off
  2. washsubsequently washed with ether

Sources & evidence

ORD record
ord-24223bd24fb04857b60125daca0e29a5
Source dataset
uspto-grants-2012_11
Patent number
US08318774B2

Reaction notes

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