HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 63199334, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Acetophenone | HCID 7410 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2,3-Dichloro-5-(trifluoromethyl)pyridine | HCID 112234 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | HCID 63199334 | HCID 63199334 | — |
Reaction Steps
To a suspension of 2.6 g (0.065 mol) of sodium hydride 60% in dimethoxyethane at room temperature is added 3.4 mL (0.029 mol) of acetophenone. After 45 min., 5.55 mL (0.038 mol) of 2,3-dichloro-5-(trifluoromethyl)pyridine is added. After 25 min., the reaction mixture is poured over 100 mL of hydrochloric acid 1N, extracted twice with 100 mL of ethyl acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318777B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-babbba041e814f888ed3bd85ae7b9df1 |
| Source note | uspto-grants-2012_11 |