Hydrochloric Acid → HCID 63199334, compound

HRID 1880775Notes

Reaction equation

HRID 1880775 reaction equation
[H-].[Na+].[C:3]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)(=[O:5])[CH3:4].Cl[C:13]1[C:18]([Cl:19])=[CH:17][C:16]([C:20]([F:23])([F:22])[F:21])=[CH:15][N:14]=1.Cl>C(COC)OC>[Cl:19][C:18]1[C:13]([CH2:4][C:3]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=2)=[O:5])=[N:14][CH:15]=[C:16]([C:20]([F:22])([F:21])[F:23])[CH:17]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7410AcetophenoneHCID 24758Sodium hydrideHCID 1122342,3-Dichloro-5-(trifluoromethyl)pyridine

Product 1

HCID 63199334HCID 63199334, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

To a suspension of 2.6 g (0.065 mol) of sodium hydride 60% in dimethoxyethane at room temperature is added 3.4 mL (0.029 mol) of acetophenone. After 45 min., 5.55 mL (0.038 mol) of 2,3-dichloro-5-(trifluoromethyl)pyridine is added. After 25 min., the reaction mixture is poured over 100 mL of hydrochloric acid 1N, extracted twice with 100 mL of ethyl acetate.

Workup

  1. waitAfter 25 min.
  2. extractionextracted twice with 100 mL of ethyl acetate

Sources & evidence

ORD record
ord-babbba041e814f888ed3bd85ae7b9df1
Source dataset
uspto-grants-2012_11
Patent number
US08318777B2

Reaction notes

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