HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl](cyano)methyl]acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Amino[3-chloro-5-(trifluoromethyl)-2-pyridinyl]acetonitrile hydrochloride | HCID 23078241 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl](cyano)methyl]acetamide | HCID 66798198 | — |
Reaction Steps
0.67 g of amino[3-chloro-5-(trifluoromethyl)-2-pyridinyl]acetonitrile hydrochloride (0.00245 mol) are dissolved in 15 mL of dichloromethane, 0.68 mL of triethylamine are added. After 10 min. at room temperature, 0.18 mL of acetyl chloride (0.00245 mol) are added, the reaction mixture is stirred overnight. The reaction is quenched with 20 mL of water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318777B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-b6bcd0b80cc6470f85a25c3e1b2b416c |
| Source note | uspto-grants-2012_11 |