Acetyl chloride → N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl](cyano)methyl]acetamide

HRID 1880784Notes

Reaction equation

HRID 1880784 reaction equation
Cl.[NH2:2][CH:3]([C:6]1[C:11]([Cl:12])=[CH:10][C:9]([C:13]([F:16])([F:15])[F:14])=[CH:8][N:7]=1)[C:4]#[N:5].C(N(CC)CC)C.[C:24](Cl)(=[O:26])[CH3:25]>ClCCl>[Cl:12][C:11]1[C:6]([CH:3]([C:4]#[N:5])[NH:2][C:24](=[O:26])[CH3:25])=[N:7][CH:8]=[C:9]([C:13]([F:15])([F:16])[F:14])[CH:10]=1

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 23078241Amino[3-chloro-5-(trifluoromethyl)-2-pyridinyl]acetonitrile hydrochloride

Product 1

HCID 66798198N-[[3-chloro-5-(trifluoromethyl)-2-pyridinyl](cyano)methyl]acetamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.67 g of amino[3-chloro-5-(trifluoromethyl)-2-pyridinyl]acetonitrile hydrochloride (0.00245 mol) are dissolved in 15 mL of dichloromethane, 0.68 mL of triethylamine are added. After 10 min. at room temperature, 0.18 mL of acetyl chloride (0.00245 mol) are added, the reaction mixture is stirred overnight. The reaction is quenched with 20 mL of water.

Workup

  1. customThe reaction is quenched with 20 mL of water

Sources & evidence

ORD record
ord-b6bcd0b80cc6470f85a25c3e1b2b416c
Source dataset
uspto-grants-2012_11
Patent number
US08318777B2

Reaction notes

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