HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4-Amino-3-fluoro-5-methoxybenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 3-Fluoro-5-methoxy-4-nitrobenzoic acid | HCID 57955522 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Amino-3-fluoro-5-methoxybenzoic acid | HCID 57955640 | — |
Reaction Steps
A solution of 3-fluoro-5-methoxy-4-nitrobenzoic acid (obtained above), HOAc (5 mL) and MeOH (5 mL) was hydrogenated using a hydrogen balloon overnight. The solution was then filtered through celite and concentrated to a red solid (590 mg, 66%). [M+H] calc'd for C8H8FNO3, 186; found 186.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318727B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-e031b782645449e59b532a8bd890201f |
| Source note | uspto-grants-2012_11 |