4-Fluoro-2-(trifluoromethyl)benzyl bromide → HCID 178460772, compound

HRID 1881065Notes

Reaction equation

HRID 1881065 reaction equation
ClC1C=CC=CC=1C[O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])NC1SC(SCC(C)(C)C(O)=O)=CN=1.Br[CH2:37][C:38]1[CH:43]=[CH:42][C:41]([F:44])=[CH:40][C:39]=1[C:45]([F:48])([F:47])[F:46].C([O:51][C:52](=[O:63])[C:53]([S:56][C:57]1[S:61][C:60]([NH2:62])=[N:59][CH:58]=1)([CH3:55])[CH3:54])C>>[F:44][C:41]1[CH:42]=[CH:43][C:38]([CH2:37][O:5][CH2:6][CH2:7][N:8]([C@H:25]2[CH2:26][CH2:27][C@H:28]([CH3:31])[CH2:29][CH2:30]2)[C:9](=[O:24])[NH:62][C:60]2[S:61][C:57]([S:56][C:53]([CH3:54])([CH3:55])[C:52]([OH:51])=[O:63])=[CH:58][N:59]=2)=[C:39]([C:45]([F:48])([F:47])[F:46])[CH:40]=1

Participants

4

Reactant 3

HCID 27375764-Fluoro-2-(trifluoromethyl)benzyl bromideHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178454946HCID 178454946, compound

Product 1

HCID 178460772HCID 178460772, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 3-{2-[3-[2-(2-chloro-benzyloxy)-ethyl]-3-(trans-4-methyl -cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid using 1-bromomethyl-4-fluoro-2-trifluoromethyl-benzene and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-4165ca5754624c5ebc73fe018ae1db40
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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