o-Xylyl bromide → HCID 178424282, compound

HRID 1881069Notes

Reaction equation

HRID 1881069 reaction equation
Cl[C:2]1[CH:35]=[CH:34][CH:33]=[CH:32][C:3]=1[CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])[NH:10][C:11]1[S:12][C:13]([S:16]CC(C)(C)C(O)=O)=[CH:14][N:15]=1.Br[CH2:37]C1C=CC=CC=1C.C([O:47][C:48](=[O:59])[C:49](SC1SC(N)=NC=1)([CH3:51])[CH3:50])C>>[CH3:50][C:49]([S:16][C:13]1[S:12][C:11]([NH:10][C:9]([N:8]([CH2:7][CH2:6][O:5][CH2:4][C:3]2[CH:32]=[CH:33][CH:34]=[CH:35][C:2]=2[CH3:37])[C@H:25]2[CH2:26][CH2:27][C@H:28]([CH3:31])[CH2:29][CH2:30]2)=[O:24])=[N:15][CH:14]=1)([CH3:51])[C:48]([OH:59])=[O:47]

Participants

4

Reactant 3

HCID 6992o-Xylyl bromideHCID 57481427Ethyl 2-[(2-amino-1,3-thiazol-5-yl)sulfanyl]-2-methylpropanoateHCID 178454946HCID 178454946, compound

Product 1

HCID 178424282HCID 178424282, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 3-{2-[3-[2-(2-chloro-benzyloxy)-ethyl]-3-(trans-4-methyl -cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid using 1-bromomethyl-2-methyl-benzene and 2-(2-amino-thiazol-5-ylsulfanyl)-2-methyl-propionic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-ec859f5528bf487c964e0c4118fa2787
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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