Bromomethylcyclopropane → HCID 178496036, compound

HRID 1881142Notes

Reaction equation

HRID 1881142 reaction equation
ClC1C=CC=CC=1[CH2:4][O:5][CH2:6][CH2:7][N:8]([C@H:25]1[CH2:30][CH2:29][C@H:28]([CH3:31])[CH2:27][CH2:26]1)[C:9](=[O:24])NC1SC(SCC(C)(C)C(O)=O)=CN=1.BrC[CH:38]1[CH2:40][CH2:39]1.C([O:43][C:44](=[O:53])[CH2:45][S:46][C:47]1[S:51][C:50]([NH2:52])=[N:49][CH:48]=1)C>>[CH:38]1([CH:6]([O:5][CH3:4])[CH2:7][N:8]([C@H:25]2[CH2:26][CH2:27][C@H:28]([CH3:31])[CH2:29][CH2:30]2)[C:9](=[O:24])[NH:52][C:50]2[S:51][C:47]([S:46][CH2:45][C:44]([OH:43])=[O:53])=[CH:48][N:49]=2)[CH2:40][CH2:39]1

Participants

4

Reactant 3

HCID 81503BromomethylcyclopropaneHCID 21455623Ethyl 2-(2-aminothiazol-5-ylthio)acetateHCID 178454946HCID 178454946, compound

Product 1

HCID 178496036HCID 178496036, compound

Procedure

The compound was prepared following an analogous procedure to the one described for the synthesis of 3-{2-[3-[2-(2-chloro-benzyloxy)-ethyl]-3-(trans-4-methyl -cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-2,2-dimethyl-propionic acid using bromomethyl -cyclopropane and (2-aminothiazol-5-ylsulfanyl) acetic acid ethyl ester.

Workup

  1. customThe compound was prepared

Sources & evidence

ORD record
ord-83e2169fd9f34ed599e2179edb93c4a7
Source dataset
uspto-grants-2012_11
Patent number
US08318778B2

Reaction notes

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