Boron tribromide → 478400-03-2

HRID 1881160Notes

Reaction equation

HRID 1881160 reaction equation
C[O:2][C:3]([C:5]1[S:9][C:8]2[CH:10]=[C:11]([O:16]C)[C:12]([O:14]C)=[CH:13][C:7]=2[C:6]=1[Cl:18])=[O:4].B(Br)(Br)Br>ClCCl>[Cl:18][C:6]1[C:7]2[CH:13]=[C:12]([OH:14])[C:11]([OH:16])=[CH:10][C:8]=2[S:9][C:5]=1[C:3]([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 12521856HCID 12521856, compound

Product 1

HCID 13575863478400-03-2

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
-20 °C

Procedure

3-Chloro-5,6-dimethoxy-benzo[b]thiophene-2-carboxylic acid methyl ester (0.2 g) was suspended in dichloromethane (10 ml) under nitrogen, cooled to −20° C. and boron tribromide (0.4 ml) was added. The resultant mixture was stirred at −20° C. for 30 min and then in cool overnight. The mixture was poured into ice-cold water, extracted into ethyl acetate and evaporated to dryness. The product was used for the next step without any purification.

Workup

  1. additionThe mixture was poured into ice-cold water
  2. extractionextracted into ethyl acetate
  3. customevaporated to dryness
  4. customThe product was used for the next step without any purification

Sources & evidence

ORD record
ord-504c820e90a945e1838d01b6b3ba3180
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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