Boron tribromide → 478400-03-2

Participants

Reaction Conditions

Reaction Steps

3-Chloro-5,6-dimethoxy-benzo[b]thiophene-2-carboxylic acid methyl ester (0.2 g) was suspended in dichloromethane (10 ml) under nitrogen, cooled to −20° C. and boron tribromide (0.4 ml) was added. The resultant mixture was stirred at −20° C. for 30 min and then in cool overnight. The mixture was poured into ice-cold water, extracted into ethyl acetate and evaporated to dryness. The product was used for the next step without any purification.

Provenance & Evidence