Sodium Hydroxide → HCID 67094222, compound

HRID 1881164Notes

Reaction equation

HRID 1881164 reaction equation
C[O:2][C:3]([C:5]1[S:9][C:8]2[CH:10]=[C:11]([O:15][CH3:16])[C:12]([OH:14])=[CH:13][C:7]=2[C:6]=1[Cl:17])=[O:4].[OH-].[Na+]>CO>[Cl:17][C:6]1[C:7]2[CH:13]=[C:12]([OH:14])[C:11]([O:15][CH3:16])=[CH:10][C:8]=2[S:9][C:5]=1[C:3]([OH:4])=[O:2]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67094484HCID 67094484, compound

Product 1

HCID 67094222HCID 67094222, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

3-Chloro-5-hydroxy-6-methoxy-benzo[b]thiophene-2-carboxylic acid methyl ester (0.5 g) was dissolved in methanol (10 ml) and 5M sodium hydroxide (10 ml) added to. The solution refluxed for two hours. Methanol was evaporated and the resultant solution was acidified with 2M hydrochloric acid. The resultant solid was dried under vacuum. The product was used for the next step without any purification.

Workup

  1. temperatureThe solution refluxed for two hours
  2. customMethanol was evaporated
  3. customThe resultant solid was dried under vacuum
  4. customThe product was used for the next step without any purification

Sources & evidence

ORD record
ord-56bb5edb8e99422c908ea103d7016a73
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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