Nitric Acid → HCID 67094293, compound

HRID 1881165Notes

Reaction equation

HRID 1881165 reaction equation
[Cl:1][C:2]1[C:3]2[CH:13]=[C:12]([OH:14])[C:11]([O:15][CH3:16])=[CH:10][C:4]=2[S:5][C:6]=1[C:7]([OH:9])=[O:8].[N+:17]([O-])([OH:19])=[O:18]>C(OCC)(=O)C.ClCCl>[Cl:1][C:2]1[C:3]2[C:13]([N+:17]([O-:19])=[O:18])=[C:12]([OH:14])[C:11]([O:15][CH3:16])=[CH:10][C:4]=2[S:5][C:6]=1[C:7]([OH:9])=[O:8]

Participants

5

Reactant 2

HCID 944Nitric AcidHCID 67094222HCID 67094222, compound

Product 1

HCID 67094293HCID 67094293, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8857Ethyl AcetateSolvent

Procedure

3-Chloro-5-hydroxy-6-methoxy-benzo[b]thiophene-2-carboxylic acid (0.28 g) was dissolved in ethyl acetate and a solution of nitric acid in dichloromethane (2M, 0.75 ml) was gradually added at 20° C. into. The solution was stirred at room temperature for 10 min and then it was poured into ice-cold water and extracted with ethyl acetate and evaporated to dryness.

Workup

  1. additionit was poured into ice-cold water
  2. extractionextracted with ethyl acetate
  3. customevaporated to dryness

Sources & evidence

ORD record
ord-dc4cfbf320c249bf93eb2cc6811801c4
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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