Nitric Acid → 4-Bromo-5-nitroveratrole

HRID 1881173Notes

Reaction equation

HRID 1881173 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([O:10][CH3:11])[C:5]([O:8][CH3:9])=[CH:6][CH:7]=1.[N+:12]([O-])([OH:14])=[O:13].O>C(O)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([O:10][CH3:11])[C:5]([O:8][CH3:9])=[CH:6][C:7]=1[N+:12]([O-:14])=[O:13]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 962WaterHCID 76114Benzene, 4-bromo-1,2-dimethoxy-

Product 1

HCID 1709684-Bromo-5-nitroveratrole

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To the solution of 4-bromoveratrole (20 g) in acetic acid (50 ml) was added 2M nitric acid (48 ml). It was stirred at room temperature for 30 min and then the reaction solution was poured into water. The resultant solid was filtered, washed with water and dried in vacuum.

Workup

  1. filtrationThe resultant solid was filtered
  2. washwashed with water
  3. customdried in vacuum

Sources & evidence

ORD record
ord-7ce940f75bca425eae04142ef7b2c15b
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

Loading…