反应详情

2-Methyl-benzothiazole-5,6-diol was dissolved in ethyl acetate and a solution of nitric acid in dichloromethane (2M, 0.38 ml) was gradually added at 20° C. into. The solution was stirred 10 min at room temperature and then it was poured into ice water and extracted into ethyl acetate and evaporated. The product was purified by column chromatography using toluene-ethyl acetate-acetic acid 8:1:1 as the eluent.

1. extractionextracted into ethyl acetate
2. customevaporated
3. customThe product was purified by column chromatography