反应详情

2,4,5-Trimethoxybenzaldehyde (20 g) was dissolved in dichloromethane (20 ml) and aluminum chloride (34.1 g) was added in small portions. The resulting mixture was stirred at room temperature for 5 hours and then poured in acidic ice water. The dichloromethane layer was separated and the water phase extracted with ethyl acetate. The combined organic layers were extracted with 1 N NaOH. The water phase was acidified with HCl and the precipitate was filtered. The product was recrystallized from toluene.

1. customThe dichloromethane layer was separated
2. extractionthe water phase extracted with ethyl acetate
3. extractionThe combined organic layers were extracted with 1 N NaOH
4. filtrationthe precipitate was filtered
5. customThe product was recrystallized from toluene