HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → HCID 15947956, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Reactant | 2,4-Dihydroxy-5-methoxybenzaldehyde | HCID 11194554 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 15947956 | HCID 15947956 | — |
Reaction Steps
2,4-Dihydroxy-5-methoxybenzaldehyde (6.0 g), benzyl bromide (9.7 g) and 1,8-diazabicyclo[5.4.0]undec-7-ene (8.6 g) in N,N-dimethylformamide (30 ml) were heated at 100° C. under nitrogen for 5 hours. After cooling to room temperature, 1 N NaOH was added and the mixture washed with ethyl acetate. The water phase was acidified with HCl and the precipitate was filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318785B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-a4e8737928624adeb493592c1b8c24a4 |
| Source note | uspto-grants-2012_11 |