Nitric Acid → HCID 67094268, compound

HRID 1881195Notes

Reaction equation

HRID 1881195 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[CH:14]=[C:13]([OH:15])[C:12]([O:16][CH3:17])=[CH:11][C:9]=2[CH:10]=1)=[O:5])[CH3:2].[N+:18]([O-])([OH:20])=[O:19]>ClCCl>[CH2:1]([O:3][C:4]([C:6]1[O:7][C:8]2[C:14]([N+:18]([O-:20])=[O:19])=[C:13]([OH:15])[C:12]([O:16][CH3:17])=[CH:11][C:9]=2[CH:10]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 67094349HCID 67094349, compound

Product 1

HCID 67094268HCID 67094268, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
-20 °C

Procedure

6-Hydroxy-5-methoxybenzofuran-2-carboxylic acid ethyl ester (1.5 g) was dissolved to dichloromethane (30 ml) and the solution cooled to −20° C. 1 M HNO3 in dichloromethane (6.4 ml) was added and after 10 minutes the mixture poured in ice water. The dichloromethane layer was separated and the water phase extracted with ethyl acetate. The combined organic phases were dried with Na2SO4 and evaporated to dryness.

Workup

  1. customThe dichloromethane layer was separated
  2. extractionthe water phase extracted with ethyl acetate
  3. dry with materialThe combined organic phases were dried with Na2SO4
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-db777380e19e4bcc8e24aa368622e567
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

Loading…