Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | HCID 67094349 | HCID 67094349 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 67094268 | HCID 67094268 | — |
Reaction Steps
6-Hydroxy-5-methoxybenzofuran-2-carboxylic acid ethyl ester (1.5 g) was dissolved to dichloromethane (30 ml) and the solution cooled to −20° C. 1 M HNO3 in dichloromethane (6.4 ml) was added and after 10 minutes the mixture poured in ice water. The dichloromethane layer was separated and the water phase extracted with ethyl acetate. The combined organic phases were dried with Na2SO4 and evaporated to dryness.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08318785B2 |
|---|
| Source dataset | uspto-grants-2012_11 |
|---|
| ORD ID | ord-db777380e19e4bcc8e24aa368622e567 |
|---|
| Source note | uspto-grants-2012_11 |
|---|
