Hydrochloric Acid → HCID 67094183, compound

Participants

Reaction Conditions

Reaction Steps

Aluminum chloride (6.62 g) was gradually added into cool acetonitrile (14.7 ml) at 10° C. and then sodium iodide (5.57 g) was added. The solution was stirred at room temperature 30 min. (3-Chloro-5,6-dimethoxy-benzo[b]thiophen-2-yl)-morpholin-4-yl-methanone (2.1 g) from Example 8 was added. The solution was stirred at 50° C. five hours and at room temperature overnight. 2N HCl (8.4 ml) was added into the cool reaction solution and then sodium sulfite (1.58 g) and water (35 ml) were added. The mixture was stirred at 40° C. 30 min. The product was filtered, washed with water and dried in vacuum.

Provenance & Evidence