Hydrochloric Acid → HCID 67094183, compound

HRID 1881221Notes

Reaction equation

HRID 1881221 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[I-].[Na+].[Cl:7][C:8]1[C:9]2[CH:24]=[C:23]([O:25]C)[C:22]([O:27]C)=[CH:21][C:10]=2[S:11][C:12]=1[C:13]([N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)=[O:14].Cl.S([O-])([O-])=O.[Na+].[Na+]>O.C(#N)C>[Cl:7][C:8]1[C:9]2[CH:24]=[C:23]([OH:25])[C:22]([OH:27])=[CH:21][C:10]=2[S:11][C:12]=1[C:13]([N:15]1[CH2:16][CH2:17][O:18][CH2:19][CH2:20]1)=[O:14]

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 5238Sodium IodideHCID 24437Sodium SulfiteHCID 6451240Aluminum(III) ChlorideHCID 67094295HCID 67094295, compound

Product 1

HCID 67094183HCID 67094183, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Conditions

Temperature
50 °C

Procedure

Aluminum chloride (6.62 g) was gradually added into cool acetonitrile (14.7 ml) at 10° C. and then sodium iodide (5.57 g) was added. The solution was stirred at room temperature 30 min. (3-Chloro-5,6-dimethoxy-benzo[b]thiophen-2-yl)-morpholin-4-yl-methanone (2.1 g) from Example 8 was added. The solution was stirred at 50° C. five hours and at room temperature overnight. 2N HCl (8.4 ml) was added into the cool reaction solution and then sodium sulfite (1.58 g) and water (35 ml) were added. The mixture was stirred at 40° C. 30 min. The product was filtered, washed with water and dried in vacuum.

Workup

  1. additionwas added
  2. stirringThe mixture was stirred at 40° C
  3. custom30 min
  4. filtrationThe product was filtered
  5. washwashed with water
  6. customdried in vacuum

Sources & evidence

ORD record
ord-0f0c5623025340f3bd5ef7b9d18ae181
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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