HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (3-Chloro-5,6-dimethoxy-benzo[b]thiophen-2-yl)-(2,6-dimethyl-morpholin-4-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2,6-Dimethylmorpholine | HCID 110862 | — |
| Reactant | 3-Chloro-5,6-dimethoxy-benzo[b]thiophene-2-carbonyl chloride | HCID 11033619 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (3-Chloro-5,6-dimethoxy-benzo[b]thiophen-2-yl)-(2,6-dimethyl-morpholin-4-yl)-methanone | HCID 67094221 | — |
Reaction Steps
3-Chloro-5,6-dimethoxy-benzo[b]thiophene-2-carbonyl chloride (2.0 g) and 2,6-dimethylmorpholine (1.82 g) was suspended in tetrahydrofuran (15 ml) and triethylamine (0.96 ml) was added and stirring continued at room temperature for weekend. Water was added, pH adjusted to 3 by HCl, and the precipitate filtered.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318785B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-61938b891d1d4019849f302b1961aca0 |
| Source note | uspto-grants-2012_11 |