Hydrochloric Acid → HCID 67094205, compound

HRID 1881234Notes

Reaction equation

HRID 1881234 reaction equation
[Cl:1][C:2]1[C:3]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([O:21]C)=[CH:15][C:4]=2[S:5][C:6]=1[C:7]([N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)=[O:8].[Cl-].[Al+3].[Cl-].[Cl-].Cl>ClCCl>[Cl:1][C:2]1[C:3]2[CH:18]=[C:17]([O:19][CH3:20])[C:16]([OH:21])=[CH:15][C:4]=2[S:5][C:6]=1[C:7]([N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14]1)=[O:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6451240Aluminum(III) ChlorideHCID 67094295HCID 67094295, compound

Product 1

HCID 67094205HCID 67094205, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(3-Chloro-5,6-dimethoxy-benzo[b]thiophen-2-yl)-morpholin-4-yl-methanone (11.8 g) from Example 8 was slurried in dichloromethane (250 ml) and aluminum chloride (33 g) was gradually added. The reaction mixture was stirred at room temperature for 24 hours. Then 6M hydrochloric acid (96 ml) was gradually added. The organic layer was dried with sodium sulphate, evaporated and dried in vacuum. The product was a mixture of two compounds and was used for the next step without any purification.

Workup

  1. dry with materialThe organic layer was dried with sodium sulphate
  2. customevaporated
  3. customdried in vacuum
  4. additiona mixture of two compounds
  5. customwas used for the next step without any purification

Sources & evidence

ORD record
ord-d64b56cc6982491dbcd42de38e6d9e67
Source dataset
uspto-grants-2012_11
Patent number
US08318785B2

Reaction notes

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