HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 2-Chloro-5-(((3aS,6aS)-5-(ethoxycarbonyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)methyl)pyridine 1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-5-chloromethylpyridine 1-oxide | HCID 12487466 | — |
| Reactant | (3AS,6AS)-5-Ethoxycarbonyl-1H-hexahydropyrrolo[3,4-B]pyrrole | HCID 43604250 | — |
| Product | 2-Chloro-5-(((3aS,6aS)-5-(ethoxycarbonyl)hexahydropyrrolo[3,4-b]pyrrol-1(2H)-yl)methyl)pyridine 1-oxide | HCID 86649563 | — |
Reaction Steps
The titled compound was prepared in analogy to examples 2.2 and 2.3 using 2-chloro-5-(chloromethyl)pyridine 1-oxide (712 mg, 4 mmol), (3aS,6aS)-ethyl hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate (1.1 g, 5.97 mmol), and K2CO3 (553 mg, 4 mmol). The obtained crude product was used without further purification in the next reaction step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08318793B2 |
| Source dataset | uspto-grants-2012_11 |
| ORD ID | ord-f6a1690384fd4803bf3d8e4e07014a2f |
| Source note | uspto-grants-2012_11 |