反应详情

温度

20 °C

Methanesulfonyl chloride (130 mmol) was added at 5° C. to a stirred solution of boc-serinol (40 mol) and triethylamine (25 ml) in dichloromethane (100 ml). The mixture was stirred at 5° C. for 5 h and at 20° C. for 20 h. Dichloromethane (200 ml) was added and the mixture was washed with an aqueous solution of sodium hydrogen carbonate (50 mM), dried (Na2SO4) and concentrated to dryness under vacuum. Chromatography of the residue on silicagel (1.2 L) eluting with hexane/ethyl:acetate (50:50) gave bis-(methanesulfonic acid ester) of boc-serinol.

1. washthe mixture was washed with an aqueous solution of sodium hydrogen carbonate (50 mM)
2. dry with materialdried (Na2SO4)
3. concentrationconcentrated to dryness under vacuum
4. washChromatography of the residue on silicagel (1.2 L) eluting with hexane/ethyl