反应详情

A flask was charged with 2,4-bis-benzyloxy-5-bromobenzoic acid (12.4 g; 30 mmol) and tetrahydrofuran (200 mL) and stirred under nitrogen until the solution was homogeneous. Lithium aluminum hydride (1.425 g; 1.25 eq.) was slowly added and the reaction was stirred until TLC indicated that the starting material had been consumed. The reaction was slowly quenched with a saturated solution of sodium sulfate (20 mL) and then filtered through celite. The solid was washed with an additional charge of tetrahydrofuran (100 mL), and the organic layers were evaporated to give 2,4-bis-benzyloxy-5-bromobenzyl alcohol (10.5 g; 26 mmol).

1. stirringthe reaction was stirred until TLC
2. customhad been consumed
3. customThe reaction was slowly quenched with a saturated solution of sodium sulfate (20 mL)
4. filtrationfiltered through celite
5. washThe solid was washed with
6. additionan additional charge of tetrahydrofuran (100 mL)
7. customthe organic layers were evaporated