Ethylamine → HCID 178463804, compound

HRID 1881417Notes

Reaction equation

HRID 1881417 reaction equation
[CH2:1]([NH2:3])[CH3:2].[Cl-].[Cl-].[CH3:6][C:7]([CH3:30])([CH3:29])[CH2:8][C:9]1[N:10]=[C:11]([CH:14](F)[CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][NH+:23]=3)=[CH:18][CH:17]=2)[NH2+:12][CH:13]=1>O1CCCC1>[CH3:6][C:7]([CH3:30])([CH3:29])[CH2:8][C:9]1[N:10]=[C:11]([CH:14]([NH:3][CH2:1][CH3:2])[CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)=[CH:18][CH:17]=2)[NH:12][CH:13]=1

Participants

4

Reactant 2

HCID 6341EthylamineHCID 66705654HCID 66705654, compound

Product 1

HCID 178463804HCID 178463804, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Ethylamine (2 M in tetrahydrofuran) (excess) was added to an ambient temperature solution of 2-(4-{2-[4-(2,2-dimethylpropyl)-1H-imidazol-1-ium-2-yl]-2-fluoroethyl}phenyl)pyridinium dichloride (for synthesis see Example 2) (10 mg, 0.03 mmol) in tetrahydrofuran (3 mL). After stirring at ambient temperature until no further reaction (LCMS), the reaction mixture was concentrated. Preparative plate chromatography eluting with 40% methanol/ethyl acetate afforded the title compound. (M+H) found: 363.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. washPreparative plate chromatography eluting with 40% methanol/ethyl acetate

Sources & evidence

ORD record
ord-b7fd7be0ad2f4ed4bb6cfcef5795072e
Source dataset
uspto-grants-2012_11
Patent number
US08318767B2

Reaction notes

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