反应详情

Trifluoroacetic acid (1 mL) was added to neat tert-butyl 4-(2,2-dimethylbutyl)-2-{2-[4-(5-fluoropyridin-2-yl)phenyl]-1-[(methylsulfonyl)amino]ethyl}-1H-imidazole-1-carboxylate. After stirring at ambient temperature for 1 h, the reaction mixture was concentrated in vacuo. The residue was partitioned between ethyl acetate and 10% aqueous sodium hydroxide. The aqueous phase was extracted with ethyl acetate. The combined organic extracts were dried (magnesium sulfate) and concentrated in vacuo. Preparatory plate chromatography eluting with 100% ethyl acetate afforded the title compound. (M+H) found: 445.

1. concentrationthe reaction mixture was concentrated in vacuo
2. customThe residue was partitioned between ethyl acetate and 10% aqueous sodium hydroxide
3. extractionThe aqueous phase was extracted with ethyl acetate
4. dry with materialThe combined organic extracts were dried (magnesium sulfate)
5. concentrationconcentrated in vacuo
6. washPreparatory plate chromatography eluting with 100% ethyl acetate