反应详情

温度

70 °C

Hydrogen chloride (4 M in 1,4-dioxane) (1 mL, 4 mmol) was added to an ambient temperature solution of tert-butyl[4-(4-{2-(acetylamino)-2-[4-(2,2-dimethylbutyl)-1H-imidazol-2-yl]ethyl}phenyl)-1-methyl-1H-pyrazol-3-yl]carbamate (Example 51) (4.2 mg, 0.01 mmol) in methanol (2 mL). After stirring at 70° C. for 1 h, volatiles were removed in vacuo. The residue was partitioned between methanol/ethyl acetate and 10% aqueous sodium hydroxide. The aqueous phase was extracted with ethyl acetate. The combined organic extracts were dried (magnesium sulfate) and concentrated in vacuo to afford the title compound. (M+H) found: 409.

1. customvolatiles were removed in vacuo
2. customThe residue was partitioned between methanol/ethyl acetate and 10% aqueous sodium hydroxide
3. extractionThe aqueous phase was extracted with ethyl acetate
4. dry with materialThe combined organic extracts were dried (magnesium sulfate)
5. concentrationconcentrated in vacuo