反应详情

温度

60 °C

3,4-dichloroacetophenone (5.39 mmol, 1.02 g) was dissolved in dimethyl sulfoxide (13 mL), and 48% hydrobromic acid (1.83 mL) was gradually added at room temperature. The mixture was stirred overnight at 60° C., and then the reactor was cooled to room temperature. The reaction solution was poured into water (50 mL) at 0° C. and stirred for about 1 hour. The precipitated solid was recovered by filtration, washed with water and dried by means of a vacuum pump to give the desired product as a pale yellow solid (0.780 g, yield 71%).

1. temperaturethe reactor was cooled to room temperature
2. stirringstirred for about 1 hour
3. filtrationThe precipitated solid was recovered by filtration
4. washwashed with water
5. customdried by means of a vacuum pump