Hydrochloric Acid → [4-(4-Amino-piperidine-1-carbonyl)-phenyl]-(4-amino-piperidin-1-yl)-methanone dihydrochloride

Participants

Reaction Steps

A mixture comprising the product from Step 1 (50 g, 0.09 mol) in 1,4-dioxane (236 ml, is treated with 4 M HCl in dioxane (236 ml). The resulting suspension is allowed to stir at room temperature overnight. The resulting suspension is filtered under vacuum and washed with diethyl ether (3×200 ml) to yield the desired product. The recovered solid is dried under vacuum for 2 days to afford the title compound. [M+H]+ 331

Provenance & Evidence