Hydrochloric Acid → HCID 66917536, compound

HRID 1881714Notes

Reaction equation

HRID 1881714 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([C:16]([N:18]3[CH2:23][CH2:22][CH:21]([NH2:24])[CH2:20][CH2:19]3)=[O:17])=[CH:12][CH:11]=2)=[O:9])[CH2:4][CH2:3]1.[ClH:25]>O1CCOCC1>[ClH:25].[ClH:25].[NH2:24][CH:21]1[CH2:22][CH2:23][N:18]([C:16]([C:13]2[CH:14]=[CH:15][C:10]([C:8]([N:5]3[CH2:6][CH2:7][CH:2]([NH2:1])[CH2:3][CH2:4]3)=[O:9])=[CH:11][CH:12]=2)=[O:17])[CH2:19][CH2:20]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66917476HCID 66917476, compound

Product 1

HCID 66917536HCID 66917536, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A mixture comprising the product from Step 1 (50 g, 0.09 mol) in 1,4-dioxane (236 ml, is treated with 4 M HCl in dioxane (236 ml). The resulting suspension is allowed to stir at room temperature overnight. The resulting suspension is filtered under vacuum and washed with diethyl ether (3×200 ml) to yield the desired product. The recovered solid is dried under vacuum for 2 days to afford the title compound. [M+H]+ 331

Workup

  1. filtrationThe resulting suspension is filtered under vacuum
  2. washwashed with diethyl ether (3×200 ml)

Sources & evidence

ORD record
ord-33f195b7184448f7aa85deb796b42cf8
Source dataset
uspto-grants-2012_11
Patent number
US08318935B2

Reaction notes

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