反应详情

Lithium hydroxide assisted hydrolysis of Step 1 intermediate (200 mg, 0.499 mmol) as described in Intermediate 1 gave 170 mg of the desired product as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 1.07 (d, J=6.3 Hz, 6H), 2.14-2.27 (m, 1H), 3.76 (d, J=6.3 Hz, 2H), 3.87 (s, 3H), 6.86 (d, J=7.8 Hz, 1H), 6.95 (d, J=4.5 Hz, 1H), 7.06 (t, J=7.8 Hz, 1H), 7.32 (d, J=7.2 Hz, 1H), 7.84 (d, J=16.2 Hz, 1H), 8.07 (d, J=16.2 Hz, 1H), 8.12-8.17 (m, 1H); APCI-MS (m/z) 373.07 (MH)+.