Methyl 4-chloro-3,5-dinitrobenzoate → 4-(2-Fluoro-5-methyl-pyridin-3-yl)-3,5-dinitro-benzoic acid methyl ester

HRID 1882233Notes

Reaction equation

HRID 1882233 reaction equation
[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7](Cl)=[C:6]([N+:14]([O-:16])=[O:15])[CH:5]=1.[F:18][C:19]1[C:24](C2C([N+]([O-])=O)=CC(C#N)=CC=2[N+]([O-])=O)=[CH:23][C:22]([CH3:39])=[CH:21][N:20]=1>>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([C:24]2[C:19]([F:18])=[N:20][CH:21]=[C:22]([CH3:39])[CH:23]=2)=[C:6]([N+:14]([O-:16])=[O:15])[CH:5]=1

Participants

3

Reactant 2

HCID 96161Methyl 4-chloro-3,5-dinitrobenzoateHCID 588801754-(2-Fluoro-5-methyl-pyridin-3-yl)-3,5-dinitro-benzonitrile

Product 1

HCID 588801744-(2-Fluoro-5-methyl-pyridin-3-yl)-3,5-dinitro-benzoic acid methyl esterYield 94%

Procedure

The title compound was prepared from 4-chloro-3,5-dinitro-benzoic acid methyl ester in 94% yield according to the procedure outline for the preparation of Compound 122. MS (ES) [m+H] calc'd for C14H10FN3O6, 336; found 336.

Sources & evidence

ORD record
ord-86c225c99aa14e6fa61db222c7251018
Source dataset
uspto-grants-2012_11
Patent number
US08318939B2

Reaction notes

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