5-Amino-3-methyl-9H-pyrido[2,3-b]indole-7-carbonitrile → 5-Amino-3-methyl-9H-pyrido[2,3-b]indole-7-carboxylic acid methyl ester

HRID 1882235Notes

Reaction equation

HRID 1882235 reaction equation
[CH3:1][O:2][C:3](=[O:24])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[C:7]([C:13]2[C:14](F)=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=2)=[C:6]([N+:21]([O-])=O)[CH:5]=1.NC1C=C(C#N)C=C2C=1C1C=C(C)C=NC=1N2>>[CH3:1][O:2][C:3]([C:4]1[CH:9]=[C:8]2[C:7]([C:13]3[CH:18]=[C:17]([CH3:19])[CH:16]=[N:15][C:14]=3[NH:10]2)=[C:6]([NH2:21])[CH:5]=1)=[O:24]

Participants

3

Reactant 2

HCID 161243115-Amino-3-methyl-9H-pyrido[2,3-b]indole-7-carbonitrileHCID 588801744-(2-Fluoro-5-methyl-pyridin-3-yl)-3,5-dinitro-benzoic acid methyl ester

Product 1

HCID 588801225-Amino-3-methyl-9H-pyrido[2,3-b]indole-7-carboxylic acid methyl esterYield 88%

Procedure

The title compound was prepared in 88% yield from example Compound 128 according to the procedure outlined for the preparation of Compound 124. MS (ES) [m+H] calc'd for C14H13N3O2, 256; found 256.

Sources & evidence

ORD record
ord-0ea0c055e4db4ca19e6bb37ea984ed96
Source dataset
uspto-grants-2012_11
Patent number
US08318939B2

Reaction notes

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