5-Iodo-3-methyl-9H-pyrido[2,3-b]indole-7-carbonitrile → 5-Iodo-3-methyl-9H-pyrido[2,3-b]indole-7-carboxylic acid methyl ester

HRID 1882236Notes

Reaction equation

HRID 1882236 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([C:9]3[CH:17]=[C:16]([CH3:18])[CH:15]=[N:14][C:10]=3[NH:11]2)=[C:7](N)[CH:6]=1)=[O:4].[I:20]C1C=C(C#N)C=C2C=1C1C=C(C)C=NC=1N2>>[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([C:9]3[CH:17]=[C:16]([CH3:18])[CH:15]=[N:14][C:10]=3[NH:11]2)=[C:7]([I:20])[CH:6]=1)=[O:4]

Participants

3

Reactant 2

HCID 161243125-Iodo-3-methyl-9H-pyrido[2,3-b]indole-7-carbonitrileHCID 588801225-Amino-3-methyl-9H-pyrido[2,3-b]indole-7-carboxylic acid methyl ester

Product 1

HCID 593787625-Iodo-3-methyl-9H-pyrido[2,3-b]indole-7-carboxylic acid methyl esterYield 69%

Procedure

The title compound was prepared in 69% yield from Compound 130 according to the procedure outlined for the preparation of Compound 125. MS (ES) [m+H] calc'd for C14H11IN2O2, 367; found 367.

Sources & evidence

ORD record
ord-0a9ef38de1d343b892f4b13d47128eb7
Source dataset
uspto-grants-2012_11
Patent number
US08318939B2

Reaction notes

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