HCID 58880047, compound → HCID 58880184, compound

HRID 1882280Notes

Reaction equation

HRID 1882280 reaction equation
[Cl:1][C:2]1[C:10]([O:11]C)=[C:9]2[C:5]([C:6]3[CH:16]=[C:15]([CH3:17])[CH:14]=[N:13][C:7]=3[NH:8]2)=[C:4]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([S:24]([CH2:27][CH3:28])(=[O:26])=[O:25])[CH:19]=2)[CH:3]=1.C(S(C1C=C(C2C=CC(O)=C3C=2C2C=C(C)C=NC=2N3)C=CC=1)(=O)=O)C>>[Cl:1][C:2]1[C:10]([OH:11])=[C:9]2[C:5]([C:6]3[CH:16]=[C:15]([CH3:17])[CH:14]=[N:13][C:7]=3[NH:8]2)=[C:4]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([S:24]([CH2:27][CH3:28])(=[O:25])=[O:26])[CH:19]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 58880047HCID 58880047, compoundHCID 588800815-(3-(ethylsulfonyl)phenyl)-3-methyl-9H-pyrido[2,3-b]indol-8-ol

Product 1

HCID 58880184HCID 58880184, compound

Procedure

The title compound was prepared from Compound 246 by using an analogous procedure to that outlined in the preparation of Compound 157. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.16 (t, J=7.33 Hz, 3H) 2.25 (s, 3H) 3.41 (q, J=7.58 Hz, 2H) 4.26 (t, J=6.44 Hz, 2H) 7.23 (s, 1H) 7.46 (s, 1H) 7.87 (t, J=7.71 Hz, 1H) 8.03 (t, J=7.20 Hz, 2H) 8.11 (s, 1H) 8.31 (s, 1H) 12.27 (br. s., 1H); [M+H] calc'd for C20H17ClN2O3S, 401.1; found, 401.3.

Sources & evidence

ORD record
ord-80e29df25dd94150b569e55e3fb552d0
Source dataset
uspto-grants-2012_11
Patent number
US08318939B2

Reaction notes

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