Hydrochloric Acid → 4-Amino-piperidine-1-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,2']bipy ridinyl-4-yl)-amide dihydrochloride

HRID 1882500Notes

Reaction equation

HRID 1882500 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:28])[NH:15][CH:16]2[CH2:21][CH2:20][N:19]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)[CH2:18][CH2:17]2)[CH2:10][CH2:9]1)(C)(C)C.[ClH:30]>CO>[ClH:30].[ClH:30].[N:19]1([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:20][CH2:21][CH:16]([NH:15][C:14]([N:11]2[CH2:12][CH2:13][CH:8]([NH2:7])[CH2:9][CH2:10]2)=[O:28])[CH2:17][CH2:18]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66630046[1-(3,4,5,6-Tetrahydro-2H-[1,2']bipyridinyl-4-ylcarbamoyl)-piperidin-4-yl]-carbamic acid tert-butyl ester

Product 1

HCID 666300924-Amino-piperidine-1-carboxylic acid (3,4,5,6-tetrahydro-2H-[1,2']bipy ridinyl-4-yl)-amide dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

[1-(3,4,5,6-Tetrahydro-2H-[1,2′]bipyridinyl-4-ylcarbamoyl)-piperidin-4-yl]-carbamic acid tert-butyl ester (0.45 g, 1.12 mmol) is treated with 4 M HCl (in dioxane)(2.5 ml) and methanol (1 ml, co-solvent) and the reaction mixture is allowed to stir at room temperature for 1 hour. The solvent is removed in vacuo and the resulting solid is dried in a vacuum oven to yield the title product.

Workup

  1. customThe solvent is removed in vacuo
  2. customthe resulting solid is dried in a vacuum oven

Sources & evidence

ORD record
ord-5cda7ee8cf154ac7a5625572baa6b02f
Source dataset
uspto-grants-2012_11
Patent number
US08318750B2

Reaction notes

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