Propargyl bromide → 1-(Prop-2-yn-1-yl)pyrrolidin-2-one

HRID 1882870Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].[CH2:7](Br)[C:8]#[CH:9]>>[CH2:9]([N:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6])[C:8]#[CH:7]

Participants

Reactant 2

HCID 7842Propargyl bromide

HCID 120252-Pyrrolidone

Product 1

HCID 124643131-(Prop-2-yn-1-yl)pyrrolidin-2-oneYield 58%

Procedure

As in Example 6, 15 g (0.18 mol) of 2-pyrrolidinone and 18.65 mL (1 equivalent) of propargyl bromide were reacted, then distilled in vacuo (66˜71° C./0.1 mmHg) to obtain 11.94 g (58% yield) of 1-propargyl pyrrolidin-2-one.

Workup

distillationdistilled in vacuo (66˜71° C./0.1 mmHg)

Sources & evidence

ORD record: ord-f943f177f41245a6b2cd922fc0b05cdd
Source dataset: uspto-grants-2004_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06759419B2

Reaction notes

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