HCID 54300444, compound → HCID 56979361, compound

HRID 1882907Notes

Reaction equation

HRID 1882907 reaction equation
[CH3:1][C:2]1([CH3:30])[C:26](=[O:27])[CH2:25][CH2:24][C@@:23]2([CH3:28])[C:3]1=[CH:4][CH2:5][C:6]1[C@H:7]3[C@:19]([CH3:29])([CH2:20][CH2:21][C:22]=12)[C@@H:10]([C@H:11]([CH3:18])[CH2:12][CH2:13][CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:9][CH2:8]3>O1CCCC1>[CH3:30][C:2]1([CH3:1])[C@@H:26]([OH:27])[CH2:25][CH2:24][C@@:23]2([CH3:28])[C:3]1=[CH:4][CH2:5][C:6]1[C@H:7]3[C@:19]([CH3:29])([CH2:20][CH2:21][C:22]=12)[C@@H:10]([C@H:11]([CH3:18])[CH2:12][CH2:13][CH2:14][CH:15]([CH3:17])[CH3:16])[CH2:9][CH2:8]3

Participants

3

Reactant 1

HCID 54300444HCID 54300444, compound

Product 1

HCID 56979361HCID 56979361, compoundYield 59.7%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4,4-Dimethylcholesta-5,8-diene-3-one (100 mg) is reduced with lithiumalurninumhydride (5 mg) in 2 ml tetrahydrofuran at room temperature. The solution is stirred for one hour. After aqueous work-up and column chromatography 4,4-dimethylcholesta-5,8-diene-3β-ol (60 mg) is isolated.

Sources & evidence

ORD record
ord-228554a827ae4153b82ed8b5cc5a52f1
Source dataset
uspto-grants-2004_07
Patent number
US06759400B2

Reaction notes

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