Methanol → Methyl 2-Fluoro-5-nitrobenzoate

HRID 1882976Notes

Reaction equation

HRID 1882976 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH3:14]O>Cl>[F:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([O:6][CH3:14])=[O:5]

Participants

4

Reactant 2

HCID 887MethanolHCID 2809972-Fluoro-5-nitrobenzoic acid

Product 1

HCID 11217860Methyl 2-Fluoro-5-nitrobenzoateYield 99%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 2-fluoro-5-nitrobenzoic acid (200 mg, 1.08 mmol) in 0.7 M HCl in methanol was stirred for 5 h. The mixture was concentrated yielding 210 mg (99%) of the title compound; which was used without further purification.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-b64e71aa7d3e4290a524ef0bd8d5100d
Source dataset
uspto-grants-2004_07
Patent number
US06759414B2

Reaction notes

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