HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-(5-Chloropyridin-2-yl)-2-[[4-(N,N-dimethylamino)piperidin-1-ylcarbonyl]amino]benzamide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | N-(5-Chloropyridin-2-yl)-2-(4-oxopiperidin-1-ylcarbonyl)aminobenzamide | HCID 21906655 | — |
| Product | N-(5-Chloropyridin-2-yl)-2-[[4-(N,N-dimethylamino)piperidin-1-ylcarbonyl]amino]benzamide Hydrochloride | HCID 21906638 | 170.2% |
Reaction Steps
Using a similar procedure to that described in Example 27, N-(5-chloropyridin-2-yl)-2-(4-oxopiperidin-1-ylcarbonyl)aminobenzamide (100 mg, 0.268 mmol) and dimethylamine (2.0 M solution, 2.7 mL, 5.4 mmol) yielded, after treatment with HCl, 100 mg of the title compound as a hydrochloride salt.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06759414B2 |
| Source dataset | uspto-grants-2004_07 |
| ORD ID | ord-1e1d1891ec8e41be88d031e410cace1a |
| Source note | uspto-grants-2004_07 |