Hydrochloric Acid → N-(5-Chloropyridin-2-yl)-2-[[4-(N,N-dimethylamino)piperidin-1-ylcarbonyl]amino]benzamide Hydrochloride

HRID 1882993Notes

Reaction equation

HRID 1882993 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:26])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:16][C:17]([N:19]2[CH2:24][CH2:23][C:22](=O)[CH2:21][CH2:20]2)=[O:18])=[N:6][CH:7]=1.[CH3:27][NH:28][CH3:29].Cl>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:26])[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[NH:16][C:17]([N:19]2[CH2:24][CH2:23][CH:22]([N:28]([CH3:29])[CH3:27])[CH2:21][CH2:20]2)=[O:18])=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 674DimethylamineHCID 21906655N-(5-Chloropyridin-2-yl)-2-(4-oxopiperidin-1-ylcarbonyl)aminobenzamide

Product 1

HCID 21906638N-(5-Chloropyridin-2-yl)-2-[[4-(N,N-dimethylamino)piperidin-1-ylcarbonyl]amino]benzamide HydrochlorideYield 170.2%

Procedure

Using a similar procedure to that described in Example 27, N-(5-chloropyridin-2-yl)-2-(4-oxopiperidin-1-ylcarbonyl)aminobenzamide (100 mg, 0.268 mmol) and dimethylamine (2.0 M solution, 2.7 mL, 5.4 mmol) yielded, after treatment with HCl, 100 mg of the title compound as a hydrochloride salt.

Workup

  1. customyielded

Sources & evidence

ORD record
ord-1e1d1891ec8e41be88d031e410cace1a
Source dataset
uspto-grants-2004_07
Patent number
US06759414B2

Reaction notes

Loading…