2-Amino-5-chloropyridine → HCID 21906375, compound

HRID 1883069Notes

Reaction equation

HRID 1883069 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([N+:14]([O-:16])=[O:15])=[C:9]([CH:13]=1)[C:10]([OH:12])=O)=[O:4].[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][N:19]=1>>[Cl:24][C:21]1[CH:22]=[CH:23][C:18]([NH:17][C:10](=[O:12])[C:9]2[CH:13]=[C:5]([C:3]([O:2][CH3:1])=[O:4])[CH:6]=[CH:7][C:8]=2[N+:14]([O-:16])=[O:15])=[N:19][CH:20]=1

Participants

3

Reactant 2

HCID 661742-Amino-5-chloropyridineHCID 149380985-(Methoxycarbonyl)-2-nitrobenzoic acid

Product 1

HCID 21906375HCID 21906375, compound

Procedure

Using a similar procedure to that described in Example 8-A, 5-methoxycarbonyl-2-nitrobenzoic acid (20 g, 89 mmol) and 2-amino-5-chloropyridine (11 g, 85 mmol) afforded, after recrystallization from toluene, 23.6 g (83%) of the title compound.

Workup

  1. customafforded
  2. customafter recrystallization from toluene, 23.6 g (83%) of the title compound

Sources & evidence

ORD record
ord-8e3c981e4eaf448cbad0ce90f920c5a2
Source dataset
uspto-grants-2004_07
Patent number
US06759414B2

Reaction notes

Loading…