Glycinamide → HCID 60083631, compound

HRID 1883122Notes

Reaction equation

[N:1]1([CH2:6][C:7]2[CH:15]=[C:14]3[C:10]([CH:11]=[C:12]([C:16]([OH:18])=O)[NH:13]3)=[CH:9][CH:8]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.N[CH2:20][C:21]([NH2:23])=[O:22]>>[C:5]([CH2:4][NH:23][C:21]([C@@H:20]1[CH2:8][CH2:9][CH2:10][CH2:11][C@@H:12]1[NH:13][C:16]([C:12]1[NH:13][C:14]2[C:10]([CH:11]=1)=[CH:9][CH:8]=[C:7]([CH2:6][N:1]1[CH:5]=[CH:4][N:3]=[CH:2]1)[CH:15]=2)=[O:18])=[O:22])#[N:1]

Participants

Reactant 2

HCID 69020Glycinamide

HCID 13663032HCID 13663032, compound

Product 1

HCID 60083631HCID 60083631, compound

Procedure

6-Imidazol-1-ylmethyl-1H-indole-2-carboxylic acid [(1S,2R)-2-(cyanomethyl-carbamoyl)-cyclohexyl]-amide was prepared from 6-imidazol-1-ylmethyl-1H-indole-2-carboxylic acid using the coupling procedure of Example 10 and replacing leucinamide with 2-aminoacetamide.

Sources & evidence

ORD record: ord-20d3f8956d504ec1bde5c99ea57b5fe4
Source dataset: uspto-grants-2004_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06759428B2

Reaction notes

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